Abstract
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Animals
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bacteria / drug effects
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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HL-60 Cells
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Humans
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K562 Cells
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Leukemia L1210
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Liriodendron / chemistry*
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Magnetic Resonance Spectroscopy
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Mice
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Plant Extracts / pharmacology*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Enzyme Inhibitors
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Plant Extracts
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Sesquiterpenes
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lipiferolide
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Alkyl and Aryl Transferases
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p21(ras) farnesyl-protein transferase