Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo

Cell Res. 2007 Apr;17(4):274-6. doi: 10.1038/cr.2007.21.

Authors

Guang-Biao Zhou¹, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen

Affiliation

¹ State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China.

PMID: 17426700
DOI: 10.1038/cr.2007.21

No abstract available

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
Cell Proliferation / drug effects
Cell Survival / drug effects
Core Binding Factor Alpha 2 Subunit / genetics
Core Binding Factor Alpha 2 Subunit / metabolism
Diterpenes / pharmacology*
Diterpenes, Kaurane / pharmacology*
Drugs, Chinese Herbal / pharmacology
Humans
Isodon / chemistry*
Leukemia, Myeloid, Acute / drug therapy*
Membrane Potential, Mitochondrial / drug effects
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Fusion / metabolism
RUNX1 Translocation Partner 1 Protein
Tumor Cells, Cultured

Substances

AML1-ETO fusion protein, human
Antineoplastic Agents, Phytogenic
Core Binding Factor Alpha 2 Subunit
Diterpenes
Diterpenes, Kaurane
Drugs, Chinese Herbal
Oncogene Proteins, Fusion
RUNX1 Translocation Partner 1 Protein
oridonin