Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

Ginny D Ho; Ana Bercovici; Deen Tulshian; William J Greenlee; Ahmad Fawzi; April Smith Torhan; Hongtao Zhang

doi:10.1016/j.bmcl.2007.03.061

Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. doi: 10.1016/j.bmcl.2007.03.061. Epub 2007 Mar 23.

Authors

Ginny D Ho¹, Ana Bercovici, Deen Tulshian, William J Greenlee, Ahmad Fawzi, April Smith Torhan, Hongtao Zhang

Affiliation

¹ Department of Chemical Research-CV & CNS, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. [email protected]

PMID: 17428659
DOI: 10.1016/j.bmcl.2007.03.061

Abstract

A series of 4-hydroxy-4-phenylpiperidines have been synthesized and bind to the nociceptin receptor with high affinity. The synthesis and structure-activity relationships at the N-1 and C-4 are described.

MeSH terms

Animals
CHO Cells
Cricetinae
Cricetulus
Humans
Ligands
Molecular Structure
Nociceptin Receptor
Piperidines / chemical synthesis
Piperidines / chemistry*
Piperidines / metabolism*
Receptors, Opioid / metabolism*
Structure-Activity Relationship

Substances

Ligands
Piperidines
Receptors, Opioid
Nociceptin Receptor