We describe a case of complete angiographic resolution of spontaneous coronary artery dissection associated sleep deprivation with a successful medical management. A 40-year-old woman presented to our emergency department with squeezing chest pain following 72 h sleep deprivation. Coronary angiography demonstrated longitudinal dissection of the middle part of the diagonal artery with TIMI III flow to the distal part of the vessel. The dissected vessel was small to intervene so we decided to treat it conservatively with antiplatelet agents and heparin. She remained free of chest pain during the hospitalization period and was discharged in good condition. We continued to treat her in the outpatient clinic with antiplatelet agents and the patient no longer complained of chest pain. At six months, coronary angiography demonstrated complete resolution of the previously dissected coronary artery.