Abstract
Vibrio cholerae lives in aquatic environments and causes cholera. Here, we show that quorum sensing enhances V. cholerae viability under certain stress conditions by upregulating the expression of RpoS, and this regulation acts through HapR, suggesting that a quorum-sensing-enhanced stress response plays a role in V. cholerae environmental survival.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Artificial Gene Fusion
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Bacterial Proteins / biosynthesis
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Bacterial Proteins / physiology
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Gene Expression Regulation, Bacterial*
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Genes, Reporter
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Hydrogen Peroxide / pharmacology
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Microbial Viability*
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Oxidative Stress*
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Quorum Sensing / physiology*
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Sigma Factor / biosynthesis
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Sigma Factor / physiology
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Up-Regulation
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Vibrio cholerae / genetics
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Vibrio cholerae / physiology*
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beta-Galactosidase / analysis
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beta-Galactosidase / genetics
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Sigma Factor
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sigma factor KatF protein, Bacteria
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Hydrogen Peroxide
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beta-Galactosidase