New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications

Nan Chiang; Charles N Serhan

doi:10.1007/s12019-006-0005-6

New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications

Compr Ther. 2006 Fall;32(3):150-7. doi: 10.1007/s12019-006-0005-6.

Authors

Nan Chiang¹, Charles N Serhan

Affiliation

¹ The Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 17435267
DOI: 10.1007/s12019-006-0005-6

Abstract

Aspirin increases anti-inflammatory aspirin-triggered lipoxin A4 levels in healthy subjects in a gender-specific manner in a randomized clinical study. Thus, formation of aspirin-triggered lipoxin A4 may provide a novel mechanism underlying aspirin's clinical benefits, and shed light on gender-dependent therapeutics of aspirin.

Publication types

Review

MeSH terms

Acetylation
Aspirin / pharmacology*
Cyclooxygenase Inhibitors / pharmacology*
Humans
Lipoxins / biosynthesis*
Neutrophils / metabolism
Randomized Controlled Trials as Topic
Sex Factors
Thromboxane B2 / antagonists & inhibitors

Substances

Cyclooxygenase Inhibitors
Lipoxins
lipoxin A4
Thromboxane B2
Aspirin