Abstract
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Differentiation / genetics*
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Cell Differentiation / immunology
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Cell Line, Tumor
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Chromosomes, Artificial / genetics
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Flow Cytometry
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Gene Dosage
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Gene Duplication*
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Gene Expression Regulation, Neoplastic / genetics
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Genes, myb / genetics*
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Genetic Testing
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Humans
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In Situ Hybridization, Fluorescence
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Karyotyping
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Leukemia-Lymphoma, Adult T-Cell / genetics*
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Mutation / genetics
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Nucleic Acid Hybridization / genetics
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RNA, Small Interfering / genetics
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Statistics, Nonparametric
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T-Lymphocytes / pathology*