Abstract
CD4 T-cell help is required for optimal memory CD8 T-cell responses. We have found that engaging preexisting CD4 Th1, but not Th2, memory cells at the time of CD8 T-cell priming results in increased CD8 effector responses to both bacterial and viral pathogens. The enhanced responses are characterized by increased numbers of cytokine-producing, antigen-specific cells. These findings suggest that engaging endogenous memory Th1 cells may increase cellular responses in an immunotherapy or vaccination setting.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD4-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Dendritic Cells / immunology
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Immunization
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Immunologic Memory*
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Listeria monocytogenes / immunology
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Listeria monocytogenes / pathogenicity
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Listeriosis / immunology
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Listeriosis / microbiology
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Listeriosis / prevention & control
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Lymphocyte Activation*
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Mice
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Mice, Inbred C57BL
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Ovalbumin / immunology
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Propionibacterium acnes / immunology
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Th1 Cells