blaVIM-2-harboring integrons isolated in India, Russia, and the United States arise from an ancestral class 1 integron predating the formation of the 3' conserved sequence

Antimicrob Agents Chemother. 2007 Jul;51(7):2636-8. doi: 10.1128/AAC.01043-06. Epub 2007 Apr 16.

Abstract

The metallo-beta-lactamase gene bla(VIM-2) was identified in a strain of Pseudomonas aeruginosa isolated in India. The integron encoding bla(VIM-2) was virtually identical to those recently found in the United States and Russia. These unusual structures are likely to have arisen from an ancestral integron predating the formation of the 3' conserved sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Transposable Elements / genetics
  • Evolution, Molecular*
  • Genes, Bacterial*
  • Humans
  • India
  • Integrons / genetics*
  • Molecular Sequence Data
  • Pseudomonas aeruginosa* / enzymology
  • Pseudomonas aeruginosa* / genetics
  • Pseudomonas aeruginosa* / isolation & purification
  • Russia
  • United States
  • beta-Lactamases / genetics*

Substances

  • DNA Transposable Elements
  • beta-lactamase bla(vim-2)
  • beta-Lactamases

Associated data

  • GENBANK/AM296017