Abstract
A recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10q found significant association of six correlated SNPs with late-onset Alzheimer's disease (AD) among Japanese. We examined the SNP with the highest statistical significance (rs3740058) in a large Caucasian American case-control cohort and the remaining five SNPs in a smaller subset of cases and controls. We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alzheimer Disease / ethnology
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Alzheimer Disease / genetics*
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Alzheimer Disease / metabolism*
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Apolipoprotein E4 / genetics
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Brain / metabolism*
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Brain / physiopathology
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Case-Control Studies
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Chromosomes, Human, Pair 10 / genetics
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Cohort Studies
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Cytoskeletal Proteins / genetics*
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DNA Mutational Analysis
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Gene Frequency
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Heterozygote
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Humans
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Polymorphism, Single Nucleotide / genetics*
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White People / genetics
Substances
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Apolipoprotein E4
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Cytoskeletal Proteins
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DNMBP protein, human