Abstract
Therapy with tumour necrosis factor-alpha (TNFalpha)-blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNFalpha did not result in reactivation of infection, suggesting only a minor role for TNFalpha during latency of persistent Salmonella infection.
MeSH terms
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Animals
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Antibodies, Blocking / administration & dosage
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Cell Line
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Etanercept
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Immunoglobulin G / administration & dosage
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Immunoglobulin G / therapeutic use*
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Injections, Intraperitoneal
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Macrophages / immunology
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Macrophages / microbiology
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Mice
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Mice, Inbred C3H
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Receptors, Tumor Necrosis Factor / administration & dosage
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Receptors, Tumor Necrosis Factor / therapeutic use*
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Recurrence
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Salmonella Infections, Animal / immunology*
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Salmonella Infections, Animal / microbiology
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Salmonella Infections, Animal / prevention & control*
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Salmonella typhimurium / immunology*
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / immunology
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Tumor Necrosis Factor-alpha / physiology
Substances
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Antibodies, Blocking
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Immunoglobulin G
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha
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Etanercept