Abstract
Population-based differences in clinical outcome after unrelated donor hematopoietic cell transplantation suggest that the significance of human leukocyte antigen (HLA) mismatching may be related to locus-specific and allele-specific differences that distinguish ethnically diverse transplant donors and recipients. We studied the risks associated with HLA-A locus mismatching in two large transplant populations from the International Histocompatibility Working Group in hematopoietic cell transplantation data set to better understand permissible and nonpermissible HLA-A mismatches.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alleles
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Blood Donors*
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Disease-Free Survival
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Donor Selection
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Genetic Variation*
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Graft Survival
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Graft vs Host Disease / etiology
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Graft vs Host Disease / prevention & control
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HLA-A2 Antigen / genetics*
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HLA-A2 Antigen / immunology*
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Hematopoietic Stem Cell Transplantation*
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Histocompatibility*
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy*
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Survival Rate
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Treatment Outcome