Abstract
A total of 106 nitric oxide-releasing derivatives of oleanolic acid were synthesized and their effects on the inhibition of anti-Fas-mediated HepG2 cell apoptosis were evaluated in vitro. Several compounds inhibited anti-Fas-mediated HepG2 cell apoptosis in a dose-dependent manner. Within this series of compounds, 8b is the most potent inhibitor. The development of new NO-releasing derivatives of oleanolic acid may aid in the design of NO-based medicines for the intervention of human liver inflammatory diseases.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Apoptosis / drug effects*
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Cell Line
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Hepatocytes / drug effects*
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Humans
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Nitric Oxide Donors / chemical synthesis
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Nitric Oxide Donors / chemistry*
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Nitric Oxide Donors / pharmacology*
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Oleanolic Acid / analogs & derivatives*
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Polycyclic Compounds / chemical synthesis
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Polycyclic Compounds / chemistry*
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Polycyclic Compounds / pharmacology*
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fas Receptor / antagonists & inhibitors
Substances
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Nitric Oxide Donors
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Polycyclic Compounds
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fas Receptor
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Oleanolic Acid