Abstract
A new study identifies the extracellular matrix (ECM) component, SPARC (secreted protein acidic, rich in cysteine), as a critical determinant of tumour burden in the APCmin/+ model of intestinal cancer.
MeSH terms
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Animals
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Gene Deletion
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Genes, APC*
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Humans
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Intestinal Neoplasms / genetics*
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Intestinal Neoplasms / metabolism
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Mice
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Neoplasm Proteins / physiology*
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Osteonectin / physiology*
Substances
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Neoplasm Proteins
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Osteonectin