Abstract
Innate immunity is directly implicated in the pathophysiology of lupus through the dendritic cell system and the activation by immune complexes of some toll-like receptors (TLR). Interferon-alpha plays a key role in the pathophysiology of lupus and represents a promising target for immune therapy. Dendritic cells are activated and able to capture large quantities of nuclear antigen-containing bodies to stimulate specific adaptive immune response.
Publication types
-
Comparative Study
-
English Abstract
-
Review
MeSH terms
-
Adolescent
-
Adult
-
Animals
-
Antigen-Antibody Complex / immunology
-
Antigens, Nuclear / immunology
-
Apoptosis / physiology
-
Autoantigens / immunology
-
Autoimmunity / immunology
-
B-Lymphocytes
-
CD4-Positive T-Lymphocytes / immunology
-
CD8-Positive T-Lymphocytes / immunology
-
Child
-
Dendritic Cells / immunology
-
Dendritic Cells / physiology
-
Disease Models, Animal
-
Female
-
Humans
-
Interferon-alpha / physiology
-
Lupus Erythematosus, Systemic / immunology
-
Lupus Erythematosus, Systemic / physiopathology*
-
Male
-
Mice
-
Toll-Like Receptors / physiology
Substances
-
Antigen-Antibody Complex
-
Antigens, Nuclear
-
Autoantigens
-
Interferon-alpha
-
Toll-Like Receptors