Immunosuppressed patients and transplant patients bear an increased risk for invasive aspergillosis and Aspergillus endophthalmitis. An 8-month-old boy developed severe unilateral panuveitis after liver transplantation. Bronchopulmonary infiltrates were present, but a pulmonary Aspergillus infection was not confirmed. An enucleation was performed in order to prevent a life-threatening disseminated Aspergillus infection.