Abstract
We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Chlorocebus aethiops
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Inhibitory Concentration 50
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Molecular Structure
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RNA, Viral / drug effects
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Replicon / drug effects
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Replicon / genetics
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Structure-Activity Relationship
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Thiourea / analogs & derivatives*
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Thiourea / chemistry
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Thiourea / pharmacology*
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Vero Cells
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Virus Replication / drug effects
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West Nile virus / drug effects*
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West Nile virus / physiology
Substances
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Antiviral Agents
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RNA, Viral
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Thiourea