HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery

ChemMedChem. 2007 Jun;2(6):811-3. doi: 10.1002/cmdc.200700048.
No abstract available

MeSH terms

  • Animals
  • Antitubercular Agents / chemical synthesis
  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology
  • Cell Line
  • Chlorocebus aethiops
  • Drug Delivery Systems
  • Drug Design*
  • Isoxazoles / chemistry
  • Leucine / analogs & derivatives
  • Leucine / chemical synthesis
  • Mefloquine / chemistry
  • Mice
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects*
  • Small Molecule Libraries* / chemistry
  • Small Molecule Libraries* / pharmacology
  • Vero Cells

Substances

  • Antitubercular Agents
  • Isoxazoles
  • Small Molecule Libraries
  • Leucine
  • leucinamide
  • Mefloquine