Multiple Aspergillus brain abscesses in immuno-competent patient with severe cranio-facial trauma

Acta Neurochir (Wien). 2007 Jun;149(6):629-32; discussion 632. doi: 10.1007/s00701-007-1148-7. Epub 2007 Apr 26.

Abstract

Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stereotactic drainage and, with Amphotericin B, Liposomal Amphotericin B, and Itraconazol.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amphotericin B / administration & dosage
  • Antifungal Agents / administration & dosage
  • Brain Abscess / diagnosis
  • Brain Abscess / drug therapy
  • Brain Abscess / immunology*
  • Brain Abscess / surgery
  • Cerebral Ventricles / surgery
  • Cerebrospinal Fluid Shunts
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Facial Injuries / surgery*
  • Humans
  • Hydrocephalus / surgery
  • Immunocompetence / immunology*
  • Itraconazole / administration & dosage
  • Male
  • Maxillary Fractures / surgery*
  • Meningitis, Fungal / diagnosis
  • Meningitis, Fungal / drug therapy
  • Meningitis, Fungal / immunology*
  • Meningitis, Fungal / surgery
  • Microsurgery
  • Motor Cortex / surgery
  • Neuroaspergillosis / diagnosis
  • Neuroaspergillosis / drug therapy
  • Neuroaspergillosis / immunology*
  • Neuroaspergillosis / surgery
  • Neuronavigation
  • Osteotomy, Le Fort
  • Postoperative Complications / diagnosis
  • Postoperative Complications / drug therapy
  • Postoperative Complications / immunology*
  • Postoperative Complications / surgery
  • Reoperation
  • Skull Fractures / surgery*
  • Tomography, X-Ray Computed

Substances

  • Antifungal Agents
  • Itraconazole
  • Amphotericin B