Abstract
K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K(V)1.5 blockers.
MeSH terms
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Atrial Fibrillation / drug therapy*
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Atrial Function / drug effects*
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Atrial Function / physiology
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Kv1.5 Potassium Channel / drug effects*
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Kv1.5 Potassium Channel / metabolism
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Models, Chemical
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Potassium Channel Blockers / chemical synthesis
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Potassium Channel Blockers / pharmacology*
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Sulfonamides / chemistry
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Sulfonamides / pharmacology*
Substances
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Benzopyrans
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Kv1.5 Potassium Channel
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Potassium Channel Blockers
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Sulfonamides