Albumin-bound toxins are important in the pathophysiology of liver failure, systemic inflammatory response syndrome, and poisoning. Due to its intrinsic ability to bind molecules, albumin has been used in blood purification techniques, such as single pass albumin dialysis, the molecular adsorbent recirculating system and the Prometheus systems. Plasma filtration adsorption dialysis is the latest technology that can combine the best processes of blood/plasma purification in order to determine a selective and effective purification of molecules implicated in liver failure.