Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital

Antimicrob Agents Chemother. 2007 Jul;51(7):2611-4. doi: 10.1128/AAC.00838-06. Epub 2007 Apr 30.

Abstract

Seven bla(IMP-1)-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86, carrying the same cassette array [bla(IMP1), aac(6')-31, and aadA1], which was plasmid located in five of the isolates. This report describes the ability of nonfermentative nosocomial pathogens to acquire and disseminate antimicrobial resistance determinants.

MeSH terms

  • Acinetobacter / drug effects
  • Acinetobacter / genetics
  • Acinetobacter / isolation & purification
  • Acinetobacter / pathogenicity
  • Amino Acid Sequence
  • Aminoglycosides / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Base Sequence
  • Brazil / epidemiology
  • Codon, Terminator
  • Cross Infection
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Gene Transfer, Horizontal
  • Genes, Bacterial*
  • Hospitals
  • Humans
  • Integrons / genetics*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Open Reading Frames
  • Plasmids / genetics
  • Pseudomonas putida / drug effects
  • Pseudomonas putida / genetics
  • Pseudomonas putida / isolation & purification
  • Pseudomonas putida / pathogenicity
  • Transcription, Genetic

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Codon, Terminator

Associated data

  • GENBANK/AJ640198
  • GENBANK/AM283489
  • GENBANK/AM283490