Abstract
We report 4 case histories in which an erosive arthritis was associated with the presence of a monoclonal gammopathy of uncertain significance. In all 4 cases, the appearance of paraprotein was noted either before or during the development of the arthritis. Two patients had a rather atypical oligoarthritis, while the others had a rheumatoid-like, symmetric polyarthritis. A synovial amyloid deposit was present in 2 patients, while mild mixed mononuclear infiltrates were the main pathologic finding in the others. In 2 patients, immunohistochemical investigation demonstrated deposits of immunoglobulin-derived material of the same isotype as the monoclonal component in the synovial tissue.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Amyloid / analysis
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Amyloid / metabolism
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Arthritis / complications*
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Arthritis / immunology
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Arthritis / metabolism
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Female
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Humans
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Immunoglobulin kappa-Chains / analysis
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Immunoglobulin kappa-Chains / metabolism
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Immunoglobulin lambda-Chains / analysis
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Immunoglobulin lambda-Chains / metabolism
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Immunohistochemistry
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Male
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Middle Aged
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Paraproteinemias / complications*
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Paraproteinemias / immunology
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Paraproteinemias / metabolism
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Paraproteins / metabolism
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Serum Amyloid A Protein / analysis
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Serum Amyloid A Protein / metabolism
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Synovial Membrane / chemistry
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Synovial Membrane / metabolism
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beta 2-Microglobulin / analysis
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beta 2-Microglobulin / metabolism
Substances
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Amyloid
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Immunoglobulin kappa-Chains
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Immunoglobulin lambda-Chains
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Paraproteins
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Serum Amyloid A Protein
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beta 2-Microglobulin