Multilevel regulation of growth rate in yeast revealed using systems biology

Arvind Ramanathan; Stuart L Schreiber

doi:10.1186/jbiol56

Multilevel regulation of growth rate in yeast revealed using systems biology

J Biol. 2007;6(2):3. doi: 10.1186/jbiol56.

Authors

Arvind Ramanathan¹, Stuart L Schreiber

Affiliation

¹ The Broad Institute of Harvard & MIT, Chemical Biology Program, 7 Cambridge Center, Cambridge, MA 02142, USA.

PMID: 17472733
PMCID: PMC2373900
DOI: 10.1186/jbiol56

Abstract

The effect of changing growth rates on the transcriptome, proteome and metabolome has been systematically studied. Measurements made under varying nutrient conditions, corresponding to biochemical pathways that correlate primarily with growth rate, reveal a central role for mitochondrial metabolism and the TOR (target of rapamycin) signaling pathway.

Publication types

Review

MeSH terms

Gene Expression Profiling
Gene Expression Regulation, Fungal / physiology*
Mitochondria / genetics
Mitochondria / metabolism
Protein Kinases / genetics
Protein Kinases / metabolism
Proteome
Saccharomyces cerevisiae / genetics
Saccharomyces cerevisiae / growth & development*
Signal Transduction
Systems Biology / methods*
TOR Serine-Threonine Kinases

Substances

Proteome
Protein Kinases
TOR Serine-Threonine Kinases