Two cases of primary biliary cirrhosis complicated by acute leukemia

Hironobu Saito; Kyoko Monoe; Yukiko Kanno; Atsushi Takahashi; Tsuyoshi Rai; Atsushi Irisawa; Hiromasa Ohira

doi:10.2169/internalmedicine.46.6037

Two cases of primary biliary cirrhosis complicated by acute leukemia

Intern Med. 2007;46(9):561-3. doi: 10.2169/internalmedicine.46.6037. Epub 2007 May 1.

Authors

Hironobu Saito¹, Kyoko Monoe, Yukiko Kanno, Atsushi Takahashi, Tsuyoshi Rai, Atsushi Irisawa, Hiromasa Ohira

Affiliation

¹ Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, Japan.

PMID: 17473489
DOI: 10.2169/internalmedicine.46.6037

Abstract

Case 1 was a 43-year-old woman, who was diagnosed as having PBC. After one month, she was hospitalized owing to sudden temporary unconsciousness. She was diagnosed as having acute lymphoid leukemia (ALL) by bone marrow examination. Chemotherapy was done, but she died after 6 months. Case 2 was a 54-year-old woman, who was diagnosed as having PBC with CREST syndrome. Seven years later, she was diagnosed as having acute promyelocytic leukemia (APL) by bone marrow examination. Chemotherapy was continued, and her symptoms are at present, stable. To date, there have been no reports of PBC complicated by acute leukemia.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Blotting, Western
CREST Syndrome / complications
Dihydrolipoyllysine-Residue Acetyltransferase / metabolism
Fatal Outcome
Female
Humans
Leukemia, Promyelocytic, Acute / complications*
Leukemia, Promyelocytic, Acute / drug therapy
Liver / pathology
Liver Cirrhosis, Biliary / complications*
Liver Cirrhosis, Biliary / enzymology
Liver Cirrhosis, Biliary / pathology
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Substances

Dihydrolipoyllysine-Residue Acetyltransferase