Simultaneous recording of neuronal signals and functional NMR imaging

Magn Reson Imaging. 2007 Jul;25(6):760-74. doi: 10.1016/j.mri.2007.03.015. Epub 2007 May 3.

Abstract

We recently directly examined the relationship between blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signals and neural activity by simultaneously acquiring electrophysiological and fMRI data from monkeys in a 4.7-T vertical scanner (Logothetis NK, Pauls J, Augath MA, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 2001;412:150-157). Acquisition of electrical signals in the microvolt range required extensive development of new recording hardware, including electrodes, microdrives, signal conditioning and interference compensation devices. Here, we provide a detailed description of the interference compensation system that can be used to record field and action potentials intracortically within a high-field scanner.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agar
  • Animals
  • Electrocardiography / methods
  • Electrodes
  • Electrophysiology
  • Equipment Design
  • Macaca
  • Magnetic Resonance Imaging / methods*
  • Metals / chemistry
  • Models, Statistical
  • Neurons / metabolism*
  • Oxygen / metabolism
  • Radio Waves
  • Time Factors

Substances

  • Metals
  • Agar
  • Oxygen