A state-of-the-art cyanation of aryl bromides: a novel and versatile copper catalyst system inspired by Nature

Chemistry. 2007;13(21):6249-54. doi: 10.1002/chem.200700079.

Abstract

A general protocol for the cyanation of aryl halides with the nontoxic cyanide source K4[Fe(CN)6] using copper catalysis and a ligand system based on 1-alkylimidazoles is presented. The advantages of this system are the high selectivity, a unique substrate range, easy handling, and inexpensive reagents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bromides / chemistry*
  • Bromobenzenes / chemistry
  • Catalysis
  • Copper / chemistry*
  • Cyanides / chemistry*
  • Molecular Structure

Substances

  • Bromides
  • Bromobenzenes
  • Cyanides
  • Copper
  • bromobenzene