Abstract
RecQ DNA helicases resolve Rad-51-mediated recombination and suppress aberrant homologous recombination. RecQ gene loss is associated with cancer susceptibility and increased mitotic recombination. We have developed an in vivo assay based on a zebrafish pigment mutant for suppression of RecQ activity, and demonstrate that zebrafish RecQ genes have conserved function in suppressing mitotic recombination.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Animals
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Bloom Syndrome / genetics
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Embryo, Nonmammalian / physiology*
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Mitosis*
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Molecular Sequence Data
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Mutation
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RNA / genetics
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RecQ Helicases / genetics*
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Recombination, Genetic*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Transcription, Genetic
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Werner Syndrome / genetics
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Zebrafish / embryology*
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Zebrafish / genetics
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Zebrafish Proteins / genetics*
Substances
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Zebrafish Proteins
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RNA
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RecQ Helicases