Abstract
Multicenter, retrospective analysis of 70 subjects with TSC following surgery for relief of epilepsy revealed significant associations between younger age at seizure onset, present/prior history of infantile spasms, interictal focality (bilateral versus unilateral), and absence of residual postoperative predominant tuber, and poorer postoperative outcome (p < 0.01). Ictal multifocality, mental retardation, and discordant EEG and MRI data showed a negative trend toward outcome, but were not significant.
MeSH terms
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Age of Onset
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Brain Mapping
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology
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Cerebral Cortex / surgery
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Child
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Child, Preschool
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Electroencephalography / statistics & numerical data
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Epilepsies, Partial / pathology
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Epilepsies, Partial / physiopathology
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Epilepsies, Partial / surgery
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Epilepsy / pathology
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Epilepsy / physiopathology
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Epilepsy / surgery
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Female
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Functional Laterality / physiology
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Humans
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Magnetic Resonance Imaging / statistics & numerical data
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Male
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Postoperative Complications
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Preoperative Care
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Retrospective Studies
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Treatment Outcome
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Tuberous Sclerosis / pathology
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Tuberous Sclerosis / physiopathology
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Tuberous Sclerosis / surgery*