Idiopathic transverse myelitis: corticosteroids, plasma exchange, or cyclophosphamide

Neurology. 2007 May 8;68(19):1614-7. doi: 10.1212/01.wnl.0000260970.63493.c8.

Abstract

Transverse myelitis is a focal disorder of the spinal cord in which an immune-mediated process results in neural injury. In this large retrospective study, we compare patients who received one of four treatments to identify the most effective therapies. We identified subsets of patients who received clinical benefit from plasma exchange or cyclophosphamide being included in their treatment regimen.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Adult
  • Autoimmune Diseases / complications
  • Autoimmune Diseases / immunology
  • Causality
  • Cyclophosphamide / administration & dosage*
  • Disability Evaluation
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Myelitis, Transverse / drug therapy*
  • Myelitis, Transverse / immunology
  • Myelitis, Transverse / physiopathology
  • Plasmapheresis / standards*
  • Plasmapheresis / statistics & numerical data
  • Retrospective Studies
  • Spinal Cord / drug effects*
  • Spinal Cord / immunology
  • Spinal Cord / physiopathology
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Cyclophosphamide