Abstract
In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alanine / analysis
-
Ammonia / analysis
-
Animals
-
Cell Division
-
Cell Line, Tumor / metabolism
-
Cell Transformation, Neoplastic / metabolism*
-
Chromans / pharmacology*
-
Culture Media, Conditioned / chemistry
-
Drug Screening Assays, Antitumor
-
Glutamic Acid / metabolism
-
Humans
-
Hydrogen-Ion Concentration*
-
Intracellular Fluid / chemistry*
-
Lymphoma, Large B-Cell, Diffuse / pathology*
-
Mice
-
NIH 3T3 Cells / drug effects
-
NIH 3T3 Cells / ultrastructure
-
Protein-Tyrosine Kinases / genetics
-
Protein-Tyrosine Kinases / physiology*
-
Sodium-Hydrogen Exchangers / antagonists & inhibitors
-
Sodium-Hydrogen Exchangers / physiology*
-
Thiazolidinediones / pharmacology*
-
Transfection
-
Troglitazone
Substances
-
Chromans
-
Culture Media, Conditioned
-
Sodium-Hydrogen Exchangers
-
Thiazolidinediones
-
Glutamic Acid
-
Ammonia
-
p80(NPM-ALK) protein
-
Protein-Tyrosine Kinases
-
Troglitazone
-
Alanine