Abstract
We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. Neither of the alleles was associated with B-CLL clinical characteristics or mortality. HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival (p=0.007, p=0.002). Our results suggest that HLA-restricted adaptive immunity influences CLL outcome.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alleles
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Female
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Gene Frequency
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Genes, MHC Class II
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HLA-DR Antigens / analysis*
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HLA-DR Antigens / genetics
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HLA-DRB1 Chains
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Humans
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Kaplan-Meier Estimate
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Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
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Leukemia, Lymphocytic, Chronic, B-Cell / mortality
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Male
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Middle Aged
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Survival Analysis
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T-Lymphocytes / immunology
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Treatment Outcome
Substances
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HLA-DR Antigens
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HLA-DRB1 Chains
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HLA-DRB1*01 antigen
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HLA-DRB1*02 antigen