Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Thomas Lecompte; Denis Wahl; Christine Perret-Guillaume; H Coenraad Hemker; Patrick Lacolley; Véronique Regnault

doi:10.3324/haematol.10577

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Haematologica. 2007 May;92(5):714-5. doi: 10.3324/haematol.10577.

Authors

Thomas Lecompte, Denis Wahl, Christine Perret-Guillaume, H Coenraad Hemker, Patrick Lacolley, Véronique Regnault

PMID: 17488705
DOI: 10.3324/haematol.10577

Abstract

Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.

Publication types

Letter

MeSH terms

Activated Protein C Resistance / blood
Activated Protein C Resistance / immunology
Adult
Aged
Antibodies, Antiphospholipid / immunology
Antiphospholipid Syndrome / blood*
Antiphospholipid Syndrome / complications
Antiphospholipid Syndrome / immunology
Female
Humans
Inhibitory Concentration 50
Lupus Coagulation Inhibitor / immunology*
Male
Middle Aged
Risk
Thrombophilia / blood*
Thrombophilia / etiology
Thrombophilia / immunology
Thrombosis / epidemiology*

Substances

Antibodies, Antiphospholipid
Lupus Coagulation Inhibitor