Chemistry of diazafulvenium methides in the synthesis of functionalized pyrazoles

J Org Chem. 2007 Jun 8;72(12):4406-15. doi: 10.1021/jo070265x. Epub 2007 May 10.

Abstract

The chemistry of diazafulvenium methides generated by the thermal extrusion of sulfur dioxide from 2,2-dioxo-1H,3H-pyrazolo[1,5-c] [1,3]thiazoles is described. The diazafulvenium methides unsubstituted at C-7 participate in [8 pi + 2 pi] cycloadditions giving pyrazolo-annulated heterocycles resulting from the addition across the 1,7-position. 1-Methyl-diazafulvenium methides and 7,7-dimethyl-diazafulvenium methides undergo intramolecular sigmatropic [1,8]H shifts giving vinyl-1H-pyrazoles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Imidazoles / chemistry*
  • Pyrazoles / chemical synthesis*
  • Sulfur Dioxide / chemistry
  • Thiazoles / chemistry

Substances

  • Imidazoles
  • Pyrazoles
  • Thiazoles
  • diazafulvene
  • Sulfur Dioxide