Abstract
Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin-angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D(1)-like (D(1) and D(5)) and D(2)-like (D(2), D(3) and D(4)) subtypes based on their structure and pharmacology. Each of the dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the central and/or peripheral nervous system; others influence epithelial transport and regulate the secretion and receptors of several humoral agents. This review summarizes the physiology of the different dopamine receptors in the regulation of blood pressure, and the relationship between dopamine receptor subtypes and hypertension.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Blood Pressure / physiology
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Dopamine / metabolism
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Gastrointestinal Tract / metabolism
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Gastrointestinal Tract / physiopathology
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Humans
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Hypertension / metabolism
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Hypertension / physiopathology*
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Kidney / metabolism
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Kidney / physiopathology
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Muscle, Smooth, Vascular / metabolism
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Muscle, Smooth, Vascular / physiopathology
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Receptors, Dopamine / metabolism
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Receptors, Dopamine / physiology*
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Receptors, Dopamine D1 / metabolism
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Receptors, Dopamine D1 / physiology
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Receptors, Dopamine D2 / metabolism
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Receptors, Dopamine D2 / physiology
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Receptors, Dopamine D3 / metabolism
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Receptors, Dopamine D3 / physiology
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Receptors, Dopamine D4 / metabolism
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Receptors, Dopamine D4 / physiology
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Receptors, Dopamine D5 / metabolism
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Receptors, Dopamine D5 / physiology
Substances
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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Receptors, Dopamine D4
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Receptors, Dopamine D5
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Dopamine