Abstract
This work concerns the asymmetric addition of methyl propiolate to aldehydes with 1,2-dimethoxyethane (DME) as additive and beta-sulfonamide alcohol titanium complex as a catalyst. The reactions proceeded under mild conditions and gave the highly functionalized chiral propargylic alcohols with high ee values and good yields. Differences between three types of ligands have also been discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemistry*
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Alkynes / chemical synthesis*
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Alkynes / chemistry
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Catalysis
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Esters / chemical synthesis*
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Esters / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry*
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Stereoisomerism
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Sulfonamides / chemistry*
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Titanium / chemistry*
Substances
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Alcohols
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Alkynes
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Esters
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Organometallic Compounds
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Sulfonamides
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Titanium