Abstract
1. Human astrocytoma cells produced biologically active interleukin-6 when treated with a variety of agents including bacterial lipopolysaccharides, viruses, and interleukin-1. 2. Both human recombinant IL-6 and IL-6 produced by stimulated astrocytes promoted differentiation of cultured neuronal cells and reduced survival time in culture. 3. Interleukin-6 and interleukin-1 stimulated the synthesis of the Alzheimer's disease beta-amyloid precursor protein. 4. Cytokines may be involved in stimulation of dystrophic neuritic sprouting, neuronal death, and amyloid deposition noted in the brains of Alzheimer's disease patients.
MeSH terms
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Alzheimer Disease / metabolism*
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Amyloid beta-Peptides / metabolism
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Amyloid beta-Protein Precursor / biosynthesis
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Animals
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Astrocytoma / metabolism
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Brain Neoplasms / metabolism
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Cell Differentiation / drug effects
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Cell Survival / drug effects
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Cytokines / metabolism*
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Cytokines / pharmacology
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Endotoxins / pharmacology
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Enzyme-Linked Immunosorbent Assay
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Humans
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Interleukin-1 / pharmacology
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Interleukin-6 / biosynthesis*
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Interleukin-6 / pharmacology
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Neurites / drug effects
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Rats
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Recombinant Proteins / pharmacology
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Tumor Cells, Cultured
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Cytokines
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Endotoxins
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Interleukin-1
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Interleukin-6
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Recombinant Proteins