Atorvastatin is 10-fold more active in vitro than other statins against Plasmodium falciparum

Antimicrob Agents Chemother. 2007 Jul;51(7):2654-5. doi: 10.1128/AAC.01330-06. Epub 2007 May 14.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Atorvastatin
  • Dose-Response Relationship, Drug
  • Heptanoic Acids / pharmacology*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • In Vitro Techniques
  • Inhibitory Concentration 50
  • Malaria, Falciparum / drug therapy
  • Microbial Sensitivity Tests
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics
  • Pyrroles / pharmacology*
  • Structure-Activity Relationship

Substances

  • Antimalarials
  • Heptanoic Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyrroles
  • Atorvastatin