Abstract
Calcineurin mutation or inhibition enhanced the antifungal morphological effect of cell wall inhibitors caspofungin or nikkomycin Z against Aspergillus fumigatus. Quantification of 1,3-beta-d-glucan revealed decreased amounts in the calcineurin A (DeltacnaA) mutant. Calcineurin can be an excellent adjunct therapeutic target in combination with other cell wall inhibitors against A. fumigatus.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aminoglycosides / pharmacology
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Antifungal Agents / pharmacology*
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Aspergillus fumigatus / drug effects*
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Aspergillus fumigatus / growth & development
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Calcineurin / genetics
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Calcineurin Inhibitors*
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Caspofungin
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Cell Wall / drug effects*
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Drug Synergism
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Echinocandins
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Enzyme Inhibitors / pharmacology
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Gene Expression Regulation, Fungal
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Humans
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Lipopeptides
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Microbial Sensitivity Tests
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Mutation*
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Peptides, Cyclic / pharmacology
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Tacrolimus / pharmacology
Substances
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Aminoglycosides
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Antifungal Agents
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Calcineurin Inhibitors
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Echinocandins
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Enzyme Inhibitors
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Lipopeptides
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Peptides, Cyclic
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nikkomycin
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Calcineurin
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Caspofungin
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Tacrolimus