Abstract
A novel dimeric bromopyrrole alkaloid, nagelamide J (1), with antimicrobial activity has been isolated from an Okinawan marine sponge Agelas species, and the structure and stereochemistry were elucidated from spectroscopic data. Nagelamide J (1) is the first bromopyrrole alkaloid possessing a cyclopentane ring fused to an amino imidazole ring.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Agelas / chemistry*
-
Alkaloids / chemistry*
-
Alkaloids / isolation & purification
-
Alkaloids / pharmacology
-
Animals
-
Cryptococcus neoformans / drug effects
-
Magnetic Resonance Spectroscopy / methods
-
Microbial Sensitivity Tests
-
Models, Molecular
-
Molecular Structure
-
Pyrroles / chemistry*
-
Pyrroles / isolation & purification
-
Pyrroles / pharmacology
-
Sensitivity and Specificity
-
Species Specificity
-
Staphylococcus aureus / drug effects
-
Structure-Activity Relationship
Substances
-
Alkaloids
-
Pyrroles
-
nagelamide J