Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene

Antimicrob Agents Chemother. 2007 Aug;51(8):3017-9. doi: 10.1128/AAC.00279-07. Epub 2007 May 21.

Abstract

This work identifies an ISCR1-related bla(CTX-M-14) gene, which has never been reported before, from a clinical isolate of Escherichia coli. The bla(CTX-M-14) gene was preceded by an ISCR1 element that was followed by a class 1 integron containing three different insert gene cassettes, i.e., dfrA12, orfF, and aadA2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Base Sequence
  • DNA Transposable Elements / genetics*
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism
  • Humans
  • Integrons / genetics*
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Pneumonia, Bacterial / microbiology
  • Sequence Analysis, DNA
  • beta-Lactamases* / genetics
  • beta-Lactamases* / metabolism

Substances

  • Anti-Bacterial Agents
  • DNA Transposable Elements
  • Escherichia coli Proteins
  • beta-lactamase CTX-M-14
  • beta-Lactamases

Associated data

  • GENBANK/EF450247