Abstract
Neurotrophins have established roles in neuronal development, synaptogenesis, and response to stress/anxious stimuli. Moreover, these agents are neuromodulators of monoaminergic, GABAergic, and cholinergic systems. Amidst a growing appreciation of the developmental neurobiology of schizophrenia--as well as the propensity for progressive brain changes--there is emergent information on abnormalities in the expression of neurotrophins in schizophrenia. This article reviews the literature on neurotrophins and schizophrenia. A schema for understanding the neurobiology of relapse in schizophrenia is offered.
MeSH terms
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Antipsychotic Agents / pharmacology
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Antipsychotic Agents / therapeutic use
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Binding Sites
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Brain / drug effects
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Brain / metabolism
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Brain / physiopathology
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Brain-Derived Neurotrophic Factor / drug effects
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Brain-Derived Neurotrophic Factor / metabolism
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Humans
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Nerve Growth Factors / drug effects
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Nerve Growth Factors / metabolism
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Nerve Growth Factors / physiology*
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Receptor, trkB / drug effects
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Receptor, trkB / metabolism
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Recurrence
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Schizophrenia / drug therapy
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Schizophrenia / metabolism*
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Schizophrenia / physiopathology
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Vascular Endothelial Growth Factor A / drug effects
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Vascular Endothelial Growth Factor A / metabolism
Substances
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Antipsychotic Agents
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Vascular Endothelial Growth Factor A
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Receptor, trkB