Unusual concurrent detection by polymerase chain reaction of Bartonella henselae and parvovirus b19 in an immunocompetent child with erythema nodosum and hepatic granulomatous disease

Diagn Microbiol Infect Dis. 2007 Sep;59(1):81-4. doi: 10.1016/j.diagmicrobio.2007.03.021. Epub 2007 May 29.

Abstract

We report an unusual case of documented Bartonella henselae genotype I from hepatic tissue in an Italian immunocompetent girl presenting with erythema nodosum and hepatic granulomata. Polymerase chain reaction (PCR) was performed on biopsied liver sample to confirm the etiologic role of B. henselae and to identify the genetic variant of this organism. A PCR on the same liver biopsy for parvovirus B19 was also positive, but the clinical meaning of this was not clear.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Bartonella Infections / complications
  • Bartonella Infections / diagnosis*
  • Bartonella Infections / drug therapy
  • Bartonella henselae / classification
  • Bartonella henselae / genetics*
  • Child, Preschool
  • Clarithromycin / therapeutic use
  • Erythema Nodosum / drug therapy
  • Erythema Nodosum / etiology*
  • Female
  • Granuloma / drug therapy
  • Granuloma / microbiology
  • Humans
  • Immunocompetence
  • Liver Diseases / drug therapy
  • Liver Diseases / microbiology
  • Parvoviridae Infections / complications
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / genetics
  • Parvovirus B19, Human / genetics*
  • Polymerase Chain Reaction

Substances

  • Anti-Bacterial Agents
  • Clarithromycin