A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides

Matthew L Clarke; Marcia B France; Jose A Fuentes; Edward J Milton; Geoffrey J Roff

doi:10.1186/1860-5397-3-18

A convenient catalyst system for microwave accelerated cross-coupling of a range of aryl boronic acids with aryl chlorides

Beilstein J Org Chem. 2007 May 30:3:18. doi: 10.1186/1860-5397-3-18.

Authors

Matthew L Clarke¹, Marcia B France, Jose A Fuentes, Edward J Milton, Geoffrey J Roff

Affiliation

¹ School of Chemistry, University of St Andrews, EaStCHEM, St Andrews, Fife, UK. [email protected]

Abstract

A convenient microwave accelerated cross-coupling procedure between aryl chlorides with a range of boronic acids has been developed. An explanation for the low reactivity of highly fluorinated boronic acids in Suzuki coupling is provided.