Abstract
Multidrug resistant HIV-1 acquired at the time of primary infection in two patients persisted for at least 5 years with and without treatment. In each patient, only one back mutation to wild-type codon in the protease gene occurred, and that was concomitantly associated with a marked CD4 cell count decrease. In both cases, infection was caused by CCR5 viruses and no rapid clinical progression to AIDS after primary infection was observed.
MeSH terms
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Adenine / analogs & derivatives
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Adenine / therapeutic use
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Anti-Retroviral Agents / therapeutic use*
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CD4 Lymphocyte Count
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Drug Resistance, Multiple, Viral / immunology
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HIV Infections / immunology
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HIV Infections / transmission*
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HIV Infections / virology
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HIV Protease Inhibitors / therapeutic use
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HIV-1 / drug effects
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HIV-1 / genetics
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HIV-1 / immunology*
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Humans
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Lamivudine / therapeutic use
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Lopinavir
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Mutation / genetics
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Mutation / immunology
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Organophosphonates / therapeutic use
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Pyrimidinones / therapeutic use
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RNA, Viral / analysis
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Reverse Transcriptase Inhibitors / therapeutic use
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Ritonavir / therapeutic use
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Tenofovir
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Viral Load
Substances
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Anti-Retroviral Agents
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HIV Protease Inhibitors
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Organophosphonates
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Pyrimidinones
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RNA, Viral
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Reverse Transcriptase Inhibitors
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Lopinavir
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Lamivudine
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Tenofovir
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Adenine
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Ritonavir