Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents

Leena Gupta; Archna Talwar; Nishi; Shraddha Palne; Suman Gupta; Prem M S Chauhan

doi:10.1016/j.bmcl.2007.04.035

Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents

Bioorg Med Chem Lett. 2007 Jul 15;17(14):4075-9. doi: 10.1016/j.bmcl.2007.04.035. Epub 2007 Apr 19.

Authors

Leena Gupta¹, Archna Talwar, Nishi, Shraddha Palne, Suman Gupta, Prem M S Chauhan

Affiliation

¹ Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, India.

PMID: 17548194
DOI: 10.1016/j.bmcl.2007.04.035

Abstract

A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 microg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / pharmacology*
Indole Alkaloids / chemical synthesis*
Indole Alkaloids / pharmacology*
Leishmania / drug effects*

Substances

8,9-dihydrocoscinamide B
Antiprotozoal Agents
Indole Alkaloids