Abstract
Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Forkhead Transcription Factors / analysis
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Forkhead Transcription Factors / genetics*
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Gene Expression Regulation, Neoplastic
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Gene Rearrangement
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Humans
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In Situ Hybridization, Fluorescence
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Lymphoma, B-Cell / genetics
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Lymphoma, Large B-Cell, Diffuse / genetics*
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Repressor Proteins / analysis
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Repressor Proteins / genetics*
Substances
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FOXP1 protein, human
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Forkhead Transcription Factors
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Repressor Proteins