Abstract
In a population-based case-control study of community acquired Clostridium difficile-associated disease (CDAD), we matched 1,233 cases to 12,330 controls. CDAD risk increased 3-fold with use of any antimicrobial agent and 6-fold with use of fluoroquinolones. Prior use of antimicrobial agents did not affect risk for CDAD after 6 months.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / pharmacology
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Case-Control Studies
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Clostridioides difficile / drug effects*
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Clostridium Infections / drug therapy*
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Clostridium Infections / epidemiology
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Community-Acquired Infections / epidemiology
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Community-Acquired Infections / microbiology
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Databases, Factual
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Drug Resistance, Multiple, Bacterial / drug effects*
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Humans
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United Kingdom / epidemiology