Pulmonary manifestations of Pyoderma gangrenosum

Presse Med. 2007 Oct;36(10 Pt 1):1395-8. doi: 10.1016/j.lpm.2007.03.031. Epub 2007 Jun 6.

Abstract

Introduction: Pyoderma gangrenosum is an uncommon ulcerative cutaneous disorder. Extracutaneous localizations are rare. Respiratory system involvement has been described in a few cases, but the pulmonary features reported were highly variable.

Case: We report two cases of patients with Pyoderma gangrenosum combining cutaneous and pulmonary manifestations. One case presented multiple nodular lesions, some with cavitation. The underlying disease was varicella-zoster virus infection. The second presented pneumonitis with bronchiolar micronodules.

Discussion: Few cases have reported Pyoderma gangrenosum with pulmonary involvement, which appears to be manifested mainly as nodules or interstitial lung disease. The principal differential diagnosis is Wegener's granulomatosis.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use
  • Biopsy
  • Diagnosis, Differential
  • Female
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Lung / pathology
  • Lung Diseases / diagnosis
  • Lung Diseases / diagnostic imaging
  • Lung Diseases / drug therapy
  • Lung Diseases / etiology*
  • Lung Diseases / pathology
  • Lung Diseases, Interstitial / diagnosis
  • Lung Diseases, Interstitial / diagnostic imaging
  • Lung Diseases, Interstitial / drug therapy
  • Lung Diseases, Interstitial / etiology
  • Lung Diseases, Interstitial / pathology
  • Male
  • Pneumonia / diagnosis
  • Pneumonia / diagnostic imaging
  • Pneumonia / drug therapy
  • Pneumonia / etiology
  • Pneumonia / pathology
  • Prednisolone / administration & dosage
  • Prednisolone / therapeutic use
  • Pulmonary Fibrosis / diagnosis
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / etiology
  • Pyoderma Gangrenosum / complications*
  • Pyoderma Gangrenosum / diagnosis
  • Pyoderma Gangrenosum / drug therapy
  • Pyoderma Gangrenosum / pathology
  • Radiography, Thoracic
  • Skin / pathology
  • Solitary Pulmonary Nodule / diagnosis
  • Solitary Pulmonary Nodule / diagnostic imaging
  • Solitary Pulmonary Nodule / drug therapy
  • Solitary Pulmonary Nodule / etiology
  • Solitary Pulmonary Nodule / pathology
  • Time Factors
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Prednisolone