Is combination therapy with betalactam plus aminoglycoside (AGL) improving the outcome of nosocomial meningitis in children?

A Ondrusova; E Grey; J Benca; B Rudinsky; M Huttova; F Bauer; M Kovac; M Sramka

Is combination therapy with betalactam plus aminoglycoside (AGL) improving the outcome of nosocomial meningitis in children?

Neuro Endocrinol Lett. 2007 Jun:28 Suppl 2:17-8.

Authors

A Ondrusova¹, E Grey, J Benca, B Rudinsky, M Huttova, F Bauer, M Kovac, M Sramka

Affiliation

¹ St. Elisabeth University, College of Health and Social Sciences, Bratislava, Slovakia.

PMID: 17558368

Abstract

We have been unable to document a benefit of a combination of aminoglycosides with betalactam or carbapenem antibiotics in nosocomial meningitis. This was similar to the cases of sepsis, where survival of patients did not improve with combination therapy. Combination therapy did not increase the chance of appropriateness of the therapy. 30% of those on combination therapy were considered as inappropriately treated in comparison to 2.8% of those on monotherapy (p<0.01).

Publication types

Comparative Study

MeSH terms

Aminoglycosides / administration & dosage*
Anti-Bacterial Agents / administration & dosage*
Carbapenems / administration & dosage
Child
Child, Preschool
Cross Infection / drug therapy*
Drug Therapy, Combination
Glycopeptides / administration & dosage
Humans
Infant
Infant, Newborn
Meningitis, Bacterial / drug therapy*
Prognosis
Retrospective Studies
Treatment Outcome
beta-Lactams / administration & dosage*

Substances

Aminoglycosides
Anti-Bacterial Agents
Carbapenems
Glycopeptides
beta-Lactams